Who is currently the U.S. Representative from Louisville?

The correct answer is John Yarmuth, who has served as the U.S. Representative for Kentucky's 3rd congressional district, which includes Louisville. Yarmuth has been in office since 2007 and is a member of the Democratic Party. He has actively participated in various committees and has been involved in issues pertinent to his constituents, including healthcare, education, and infrastructure.

In contrast, the other individuals listed serve in different capacities. Rand Paul is a U.S. Senator from Kentucky, not a representative from Louisville. Mitch McConnell, also a U.S. Senator, holds a leadership role in the Senate and is associated with national legislative strategies rather than representing a specific congressional district. Andy Barr is the U.S. Representative for Kentucky's 6th congressional district, which primarily covers central and southeastern Kentucky, further distinguishing his role from that of Yarmuth. Therefore, within the context of the congressional representation of Louisville specifically, John Yarmuth is the appropriate choice.